Host-Microbe Core  >  Gnotobiotic Mouse Component

This component offers:

Consultations about models, resources and scientific merit of gnotobiotic studies

To request a consultation click here

Maintenance and analysis of germ-free mouse strains

To request maintenance and analysis of germ-free mouse strains click here

Gnotobiotic colonization of germ-free animals and subsequent analysis

To request gnotobiotic colonization and analysis component click here

For questions about these services contact:

Betty Theriault, D.V.M., DACLAM

Gnotobiotic Mouse Component Co-Director
Phone: 773-702-9362 Email:

Alexander Chervonsky, M.D., Ph.D.

Gnotobiotic Mouse Component Director
Phone: 773-702-1371 E-mail:

Dr. Alexander Chervonsky is doing basic research in the areas of intestinal microbial sampling and autoimmunity (Type 1 diabetes, T1D).  Dr. Chervonsky was trained at the Jackson Laboratory as a mouse geneticist and has established the germ-free facility at the University of Chicago.  He employs methods of gnotobiotic association of the germ-free mice to study the role of different microbes in generation of tolerance to pancreatic antigens in T1D. He also uses this approach to study the bacteria-induced transformation of intestinal epithelium in microbe-sampling cells.  He is involved in many collaborative studies with other investigators at the University.  His work is supported by grants from the NIH and the Juvenile Diabetes Research Foundation.  In addition to his DDRCC duties, Dr. Chervonsky is Chair of Committee on Immunology.